1gxr
From Proteopedia
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Revision as of 13:17, 30 October 2007
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WD40 REGION OF HUMAN GROUCHO/TLE1
Overview
Groucho (Gro)/TLE proteins are transcriptional corepressors that lack, inherent DNA binding but interact with DNA-bound transcription factors and, histones, and recruit histone deacetylases. Groucho-mediated repression is, essential in embryonic development and involved in regulation of Wnt, signaling in adult tissue. We have determined the 1.6 A crystal structure, of a C-terminal fragment of human Groucho/TLE1, comprising part of the, Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions. The structure confirms the, relationship to the yeast Tup1 corepressor, but reveals important, structural differences specific to the metazoan system. Analysis of, missense mutations in the C. elegans Groucho homolog UNC-37 identifies, sites ... [(full description)]
About this Structure
1GXR is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Structure known Active Site: CA. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor., Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH, Structure. 2002 Jun;10(6):751-61. PMID:12057191
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