2o8m
From Proteopedia
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{{STRUCTURE_2o8m| PDB=2o8m | SCENE= }} | {{STRUCTURE_2o8m| PDB=2o8m | SCENE= }} | ||
===Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease=== | ===Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease=== | ||
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{{ABSTRACT_PUBMED_17444623}} | {{ABSTRACT_PUBMED_17444623}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2o8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8M OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017444623</ref><references group="xtra"/> |
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
| - | [[Category: Hydrolase]] | ||
[[Category: Fischmann, T O.]] | [[Category: Fischmann, T O.]] | ||
[[Category: Madison, V M.]] | [[Category: Madison, V M.]] | ||
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[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:22:03 2009'' | ||
Revision as of 12:04, 7 January 2013
Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease
Template:ABSTRACT PUBMED 17444623
About this Structure
2o8m is a 4 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
- Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl] - 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J Med Chem. 2007 May 17;50(10):2310-8. Epub 2007 Apr 20. PMID:17444623 doi:10.1021/jm060173k
