1w7x
From Proteopedia
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==Overview== | ==Overview== | ||
| - | We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere | + | We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway. |
==Disease== | ==Disease== | ||
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[[Category: Ackermann, J.]] | [[Category: Ackermann, J.]] | ||
[[Category: Alig, L.]] | [[Category: Alig, L.]] | ||
| - | [[Category: Banner, D | + | [[Category: Banner, D W.]] |
| - | [[Category: Boehm, H | + | [[Category: Boehm, H J.]] |
[[Category: Groebke-Zbinden, K.]] | [[Category: Groebke-Zbinden, K.]] | ||
[[Category: Hilpert, K.]] | [[Category: Hilpert, K.]] | ||
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[[Category: Riederer, M.]] | [[Category: Riederer, M.]] | ||
[[Category: Stahl, M.]] | [[Category: Stahl, M.]] | ||
| - | [[Category: Tschopp, T | + | [[Category: Tschopp, T B.]] |
[[Category: Weber, L.]] | [[Category: Weber, L.]] | ||
| - | [[Category: Wessel, H | + | [[Category: Wessel, H P.]] |
[[Category: 413]] | [[Category: 413]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:41:30 2008'' |
Revision as of 13:41, 21 February 2008
|
FACTOR7- 413 COMPLEX
Contents |
Overview
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
Disease
Known diseases associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
1W7X is a Protein complex structure of sequences from Homo sapiens with , , and as ligands. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138
Page seeded by OCA on Thu Feb 21 15:41:30 2008
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Ackermann, J. | Alig, L. | Banner, D W. | Boehm, H J. | Groebke-Zbinden, K. | Hilpert, K. | Kuehne, H. | Lave, T. | Obst-Sander, U. | Riederer, M. | Stahl, M. | Tschopp, T B. | Weber, L. | Wessel, H P. | 413 | CA | GOL | SO4 | Coagulation | Enzyme complex | Serine protease
