1w8k
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine | + | Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Plasmodium vivax]] | [[Category: Plasmodium vivax]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bentley, G | + | [[Category: Bentley, G A.]] |
| - | [[Category: Chesne-Seck, M | + | [[Category: Chesne-Seck, M L.]] |
| - | [[Category: Kocken, C | + | [[Category: Kocken, C H.M.]] |
| - | [[Category: Normand, B | + | [[Category: Normand, B Vulliez-Le.]] |
| - | [[Category: Pizarro, J | + | [[Category: Pizarro, J C.]] |
| - | [[Category: Thomas, A | + | [[Category: Thomas, A W.]] |
[[Category: IMD]] | [[Category: IMD]] | ||
[[Category: antigen]] | [[Category: antigen]] | ||
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[[Category: plasmodium antigen]] | [[Category: plasmodium antigen]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:41:35 2008'' |
Revision as of 13:41, 21 February 2008
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CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX
Overview
Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design.
About this Structure
1W8K is a Single protein structure of sequence from Plasmodium vivax with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of the malaria vaccine candidate apical membrane antigen 1., Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA, Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24. PMID:15731407
Page seeded by OCA on Thu Feb 21 15:41:35 2008
