2hej
From Proteopedia
(Difference between revisions)
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[[Image:2hej.png|left|200px]] | [[Image:2hej.png|left|200px]] | ||
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{{STRUCTURE_2hej| PDB=2hej | SCENE= }} | {{STRUCTURE_2hej| PDB=2hej | SCENE= }} | ||
===Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP(H) in a closed conformation=== | ===Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP(H) in a closed conformation=== | ||
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{{ABSTRACT_PUBMED_17034817}} | {{ABSTRACT_PUBMED_17034817}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2hej]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEJ OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017034817</ref><ref group="xtra">PMID:019075558</ref><references group="xtra"/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Breton, R.]] | [[Category: Breton, R.]] | ||
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[[Category: Hsd]] | [[Category: Hsd]] | ||
[[Category: Hydroxysteroid dehydrogenase]] | [[Category: Hydroxysteroid dehydrogenase]] | ||
| - | + | [[Category: Oxidoreductase]] | |
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Revision as of 12:15, 7 January 2013
Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP(H) in a closed conformation
Template:ABSTRACT PUBMED 17034817
About this Structure
2hej is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Faucher F, Pereira de Jesus-Tran K, Cantin L, Luu-The V, Labrie F, Breton R. Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. J Mol Biol. 2006 Dec 8;364(4):747-63. Epub 2006 Sep 16. PMID:17034817 doi:http://dx.doi.org/10.1016/j.jmb.2006.09.030
- Faucher F, Cantin L, Luu-The V, Labrie F, Breton R. Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Biochemistry. 2008 Dec 23;47(51):13537-46. PMID:19075558 doi:10.1021/bi801276h
