1wcy

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(New page: 200px<br /> <applet load="1wcy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wcy, resolution 2.2&Aring;" /> '''Crystal Structure Of...)
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[[Image:1wcy.gif|left|200px]]<br /><applet load="1wcy" size="350" color="white" frame="true" align="right" spinBox="true"
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<applet load="1wcy" size="450" color="white" frame="true" align="right" spinBox="true"
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caption="1wcy, resolution 2.2&Aring;" />
caption="1wcy, resolution 2.2&Aring;" />
'''Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A'''<br />
'''Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A'''<br />
==Overview==
==Overview==
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Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the, prolyl oligopeptidase (POP) family, and has been implicated in several, diseases. Therefore, it seems important to develop selective inhibitors, for human DPPIV (hDPPIV) that are able to control the biological function, of hDPPIV. In order to elucidate the binding mode and substrate, specificity, we determined the crystal structure complex of hDPPIV and, diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2, A resolution. In this paper, we discuss the molecular interaction, mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.
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Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.
==About this Structure==
==About this Structure==
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1WCY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WCY OCA].
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1WCY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCY OCA].
==Reference==
==Reference==
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[[Category: serine protease]]
[[Category: serine protease]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:49:13 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:43:07 2008''

Revision as of 13:43, 21 February 2008

Image:1wcy.gif

1wcy, resolution 2.2Å

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Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A

Overview

Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.

About this Structure

1WCY is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.

Reference

The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A., Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R, Biol Chem. 2004 Jun;385(6):561-4. PMID:15255191

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