1gzc

From Proteopedia

Revision as of 13:18, 30 October 2007

HIGH-RESOLUTION CRYSTAL STRUCTURE OF ERYTHRINA CRISTAGALLI LECTIN IN COMPLEX WITH LACTOSE

Overview

The primary sequence of Erythrina cristagalli lectin (ECL) was mapped by, mass spectrometry, and the crystal structures of the lectin in complex, with lactose and 2'-alpha-L-fucosyllactose were determined at 1.6A and, 1.7A resolution, respectively. The two complexes were compared with the, crystal structure of the closely related Erythrina corallodendron lectin, (ECorL) in complex with lactose, with the crystal structure of the Ulex, europaeus lectin II in complex with 2'-alpha-L-fucosyllactose, and with, two modeled complexes of ECorL with, 2'-alpha-L-fucosyl-N-acetyllactosamine. The molecular models are very, similar to the crystal structure of ECL in complex with, 2'-alpha-L-fucosyllactose with respect to the overall mode of binding, with the L-fucose fitting snugly into the cavity ... [(full description)]

About this Structure

1GZC is a [Single protein] structure of sequence from [Eukaryota] with LAT, MN and CA as [ligands]. Structure known Active Site: MNA. Full crystallographic information is available from [OCA].

Reference

High-resolution crystal structures of Erythrina cristagalli lectin in complex with lactose and 2'-alpha-L-fucosyllactose and correlation with thermodynamic binding data., Svensson C, Teneberg S, Nilsson CL, Kjellberg A, Schwarz FP, Sharon N, Krengel U, J Mol Biol. 2002 Aug 2;321(1):69-83. PMID:12139934

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