1wnh
From Proteopedia
(New page: 200px<br /><applet load="1wnh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wnh, resolution 1.83Å" /> '''Crystal structure of...) |
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| - | [[Image:1wnh.gif|left|200px]]<br /><applet load="1wnh" size=" | + | [[Image:1wnh.gif|left|200px]]<br /><applet load="1wnh" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1wnh, resolution 1.83Å" /> | caption="1wnh, resolution 1.83Å" /> | ||
'''Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)'''<br /> | '''Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Latexin, the only known mammalian carboxypeptidase inhibitor, has no | + | Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. Latexin is expressed in the developing brain, and we find that it plays a role in inflammation, as it is expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets. The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors. Furthermore, despite a lack of detectable sequence duplication, the structure incorporates two topologically analogous domains related by pseudo two-fold symmetry. Surprisingly, these domains share a cystatin fold architecture found in proteins that inhibit cysteine proteases, suggesting an evolutionary and possibly functional relationship. The structure of the tumor suppressor protein TIG1 was modeled, revealing its putative membrane binding surface. |
==About this Structure== | ==About this Structure== | ||
| - | 1WNH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1WNH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Aagaard, A.]] | [[Category: Aagaard, A.]] | ||
[[Category: Cowieson, N.]] | [[Category: Cowieson, N.]] | ||
| - | [[Category: Flanagan, J | + | [[Category: Flanagan, J U.]] |
[[Category: Huber, T.]] | [[Category: Huber, T.]] | ||
| - | [[Category: Hume, D | + | [[Category: Hume, D A.]] |
[[Category: Kobe, B.]] | [[Category: Kobe, B.]] | ||
[[Category: Listwan, P.]] | [[Category: Listwan, P.]] | ||
| - | [[Category: Martin, J | + | [[Category: Martin, J L.]] |
[[Category: Ravasi, T.]] | [[Category: Ravasi, T.]] | ||
| - | [[Category: Wells, C | + | [[Category: Wells, C A.]] |
[[Category: bi-cystatin fold]] | [[Category: bi-cystatin fold]] | ||
[[Category: cis-proline]] | [[Category: cis-proline]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:46:15 2008'' |
Revision as of 13:46, 21 February 2008
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Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)
Overview
Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. Latexin is expressed in the developing brain, and we find that it plays a role in inflammation, as it is expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets. The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors. Furthermore, despite a lack of detectable sequence duplication, the structure incorporates two topologically analogous domains related by pseudo two-fold symmetry. Surprisingly, these domains share a cystatin fold architecture found in proteins that inhibit cysteine proteases, suggesting an evolutionary and possibly functional relationship. The structure of the tumor suppressor protein TIG1 was modeled, revealing its putative membrane binding surface.
About this Structure
1WNH is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1., Aagaard A, Listwan P, Cowieson N, Huber T, Ravasi T, Wells CA, Flanagan JU, Kellie S, Hume DA, Kobe B, Martin JL, Structure. 2005 Feb;13(2):309-17. PMID:15698574
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