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1wq6

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(New page: 200px<br /> <applet load="1wq6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wq6, resolution 2.00&Aring;" /> '''The tetramer struct...)
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'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''<br />
'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''<br />
==Overview==
==Overview==
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AML1/ETO is the chimeric protein resulting from the t(8;21) in acute, myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates, oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved, the NHR2 domain structure and found it to be an alpha-helical tetramer. We, show that oligomerization contributes to AML1/ETO's inhibition of, granulocyte differentiation, is essential for its ability to enhance the, clonogenic potential of primary mouse bone marrow cells, and affects, AML1/ETO's activity on several endogenous genes. Oligomerization is also, required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not, with other corepressor molecules.
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AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.
==About this Structure==
==About this Structure==
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1WQ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WQ6 OCA].
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1WQ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ6 OCA].
==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Bushweller, J.H.]]
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[[Category: Bushweller, J H.]]
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[[Category: Cheney, M.D.]]
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[[Category: Cheney, M D.]]
[[Category: Chruszcz, M.]]
[[Category: Chruszcz, M.]]
[[Category: Dauter, Z.]]
[[Category: Dauter, Z.]]
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[[Category: Hartman, K.L.]]
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[[Category: Hartman, K L.]]
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[[Category: Laue, T.M.]]
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[[Category: Laue, T M.]]
[[Category: Liu, Y.]]
[[Category: Liu, Y.]]
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[[Category: Lukasik, S.M.]]
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[[Category: Lukasik, S M.]]
[[Category: Minor, W.]]
[[Category: Minor, W.]]
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[[Category: Speck, N.A.]]
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[[Category: Speck, N A.]]
[[Category: aml1-eto]]
[[Category: aml1-eto]]
[[Category: eto]]
[[Category: eto]]
[[Category: nhr2]]
[[Category: nhr2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:47:02 2008''

Revision as of 13:47, 21 February 2008

Image:1wq6.gif

1wq6, resolution 2.00Å

Drag the structure with the mouse to rotate

The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity

Overview

AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.

About this Structure

1WQ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:16616331

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