1wvo
From Proteopedia
(New page: 200px<br /> <applet load="1wvo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wvo" /> '''Solution structure of RSGI RUH-029, an anti...) |
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'''Solution structure of RSGI RUH-029, an antifreeze protein like domain in human N-acetylneuraminic acid phosphate synthase gene.'''<br /> | '''Solution structure of RSGI RUH-029, an antifreeze protein like domain in human N-acetylneuraminic acid phosphate synthase gene.'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the C-terminal antifreeze-like (AFL) domain of human | + | The structure of the C-terminal antifreeze-like (AFL) domain of human sialic acid synthase was determined by NMR spectroscopy. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins. Evolutionary trace analyses of the type III antifreeze protein family suggested that the class-specific residues in the human and bacterial AFL domains are important for their substrate binding, while the class-specific residues of the fish antifreeze proteins are gathered on the ice-binding surface. |
==About this Structure== | ==About this Structure== | ||
| - | 1WVO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1WVO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WVO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Hirota, H.]] | [[Category: Hirota, H.]] | ||
[[Category: Ito, Y.]] | [[Category: Ito, Y.]] | ||
| - | [[Category: RSGI, RIKEN | + | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] |
[[Category: Yokoyama, S.]] | [[Category: Yokoyama, S.]] | ||
[[Category: antifreeze protein like domain]] | [[Category: antifreeze protein like domain]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:48:44 2008'' |
Revision as of 13:48, 21 February 2008
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Solution structure of RSGI RUH-029, an antifreeze protein like domain in human N-acetylneuraminic acid phosphate synthase gene.
Overview
The structure of the C-terminal antifreeze-like (AFL) domain of human sialic acid synthase was determined by NMR spectroscopy. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins. Evolutionary trace analyses of the type III antifreeze protein family suggested that the class-specific residues in the human and bacterial AFL domains are important for their substrate binding, while the class-specific residues of the fish antifreeze proteins are gathered on the ice-binding surface.
About this Structure
1WVO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the antifreeze-like domain of human sialic acid synthase., Hamada T, Ito Y, Abe T, Hayashi F, Guntert P, Inoue M, Kigawa T, Terada T, Shirouzu M, Yoshida M, Tanaka A, Sugano S, Yokoyama S, Hirota H, Protein Sci. 2006 May;15(5):1010-6. Epub 2006 Apr 5. PMID:16597820
Page seeded by OCA on Thu Feb 21 15:48:44 2008
Categories: Homo sapiens | Single protein | Hamada, T. | Hayashi, F. | Hirota, H. | Ito, Y. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Yokoyama, S. | Antifreeze protein like domain | N-acetylneuraminic acid phosphate synthase | National project on protein structural and functional analyses | Nmr | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomics
