2h6m
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2h6m.png|left|200px]] | [[Image:2h6m.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2h6m", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2h6m| PDB=2h6m | SCENE= }} | {{STRUCTURE_2h6m| PDB=2h6m | SCENE= }} | ||
===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors=== | ===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_16860823}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 16860823 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_16860823}} | {{ABSTRACT_PUBMED_16860823}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2h6m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6M OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016860823</ref><ref group="xtra">PMID:016288920</ref><references group="xtra"/> |
[[Category: Hepatitis a virus]] | [[Category: Hepatitis a virus]] | ||
[[Category: Picornain 3C]] | [[Category: Picornain 3C]] | ||
| Line 31: | Line 19: | ||
[[Category: Yin, J.]] | [[Category: Yin, J.]] | ||
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
| - | + | [[Category: Hydrolase-hydrolase inhibitor complex]] | |
| - | + | ||
Revision as of 15:04, 7 January 2013
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors
Template:ABSTRACT PUBMED 16860823
About this Structure
2h6m is a 2 chain structure with sequence from Hepatitis a virus. Full crystallographic information is available from OCA.
Reference
- Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN. An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:16860823 doi:10.1016/j.jmb.2006.06.047
- Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN. Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:16288920 doi:10.1016/j.jmb.2005.09.074
