1x11
From Proteopedia
(New page: 200px<br /> <applet load="1x11" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x11, resolution 2.5Å" /> '''X11 PTB DOMAIN'''<br...) |
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| - | [[Image:1x11.gif|left|200px]]<br /> | + | [[Image:1x11.gif|left|200px]]<br /><applet load="1x11" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1x11" size=" | + | |
caption="1x11, resolution 2.5Å" /> | caption="1x11, resolution 2.5Å" /> | ||
'''X11 PTB DOMAIN'''<br /> | '''X11 PTB DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the phosphotyrosine-binding domain (PTB) of the | + | The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1X11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1X11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X11 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Kuriyan, J.]] | [[Category: Kuriyan, J.]] | ||
| - | [[Category: Lee, C | + | [[Category: Lee, C H.]] |
[[Category: Zhang, Z.]] | [[Category: Zhang, Z.]] | ||
[[Category: complex (peptide binding module/peptide)]] | [[Category: complex (peptide binding module/peptide)]] | ||
[[Category: ptb domain]] | [[Category: ptb domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:50:03 2008'' |
Revision as of 13:50, 21 February 2008
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X11 PTB DOMAIN
Contents |
Overview
The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
Disease
Known diseases associated with this structure: Alzheimer disease-1, APP-related OMIM:[104760], Amyloidosis, cerebroarterial, Dutch type OMIM:[104760], Amyloidosis, cerebroarterial, Iowa type OMIM:[104760], Blood group, P system OMIM:[607922]
About this Structure
1X11 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain., Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J, EMBO J. 1997 Oct 15;16(20):6141-50. PMID:9321393
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