1x1z
From Proteopedia
(New page: 200px<br /><applet load="1x1z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x1z, resolution 1.45Å" /> '''Orotidine 5'-monopho...) |
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| - | [[Image:1x1z.gif|left|200px]]<br /><applet load="1x1z" size=" | + | [[Image:1x1z.gif|left|200px]]<br /><applet load="1x1z" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1x1z, resolution 1.45Å" /> | caption="1x1z, resolution 1.45Å" /> | ||
'''Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)'''<br /> | '''Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1X1Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus] with BMP and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] Full crystallographic information is available from [http:// | + | 1X1Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus] with <scene name='pdbligand=BMP:'>BMP</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X1Z OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Orotidine-5'-phosphate decarboxylase]] | [[Category: Orotidine-5'-phosphate decarboxylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Annedi, S | + | [[Category: Annedi, S C.]] |
| - | [[Category: Bello, A | + | [[Category: Bello, A M.]] |
[[Category: Fujihashi, M.]] | [[Category: Fujihashi, M.]] | ||
| - | [[Category: Kotra, L | + | [[Category: Kotra, L P.]] |
| - | [[Category: Pai, E | + | [[Category: Pai, E F.]] |
[[Category: Poduch, E.]] | [[Category: Poduch, E.]] | ||
[[Category: Wei, L.]] | [[Category: Wei, L.]] | ||
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[[Category: orotidine 5'-monophosphate decarboxylase (odcase)]] | [[Category: orotidine 5'-monophosphate decarboxylase (odcase)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:50:16 2008'' |
Revision as of 13:50, 21 February 2008
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Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)
Overview
Orotidine-5'-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position of orotidine-5'-monophosphate. We reveal an unusual biochemical pathway of conversion of 6-cyano-uridine-5'-monophosphate by ODCase to barbiturate-5'-monophosphate via perhaps an electrophilic center at the C6 position, leading to inhibition. This potential of ODCase is very useful in the design of novel inhibitors.
About this Structure
1X1Z is a Single protein structure of sequence from Methanothermobacter thermautotrophicus with and as ligands. Active as Orotidine-5'-phosphate decarboxylase, with EC number 4.1.1.23 Full crystallographic information is available from OCA.
Reference
An unprecedented twist to ODCase catalytic activity., Fujihashi M, Bello AM, Poduch E, Wei L, Annedi SC, Pai EF, Kotra LP, J Am Chem Soc. 2005 Nov 2;127(43):15048-50. PMID:16248642
Page seeded by OCA on Thu Feb 21 15:50:16 2008
Categories: Methanothermobacter thermautotrophicus | Orotidine-5'-phosphate decarboxylase | Single protein | Annedi, S C. | Bello, A M. | Fujihashi, M. | Kotra, L P. | Pai, E F. | Poduch, E. | Wei, L. | BMP | GOL | 6-cyanoump | Barbituric acid ribosyl 5'-monophosphate (bmp) | Orotidine 5'-monophosphate decarboxylase (odcase)
