3cth

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Revision as of 18:23, 7 January 2013

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Template:STRUCTURE 3cth

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor

Template:ABSTRACT PUBMED 18479916

About this Structure

3cth is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Cai ZW, Wei D, Schroeder GM, Cornelius LA, Kim K, Chen XT, Schmidt RJ, Williams DK, Tokarski JS, An Y, Sack JS, Manne V, Kamath A, Zhang Y, Marathe P, Hunt JT, Lombardo LJ, Fargnoli J, Borzilleri RM. Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3224-9. Epub 2008 Apr 25. PMID:18479916 doi:10.1016/j.bmcl.2008.04.047