3dbe

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Image:3dbe.png

Template:STRUCTURE 3dbe

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 557

Template:ABSTRACT PUBMED 18793847

About this Structure

3dbe is a 1 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA.

Reference

  • Fucini RV, Hanan EJ, Romanowski MJ, Elling RA, Lew W, Barr KJ, Zhu J, Yoburn JC, Liu Y, Fahr BT, Fan J, Lu Y, Pham P, Choong IC, VanderPorten EC, Bui M, Purkey HE, Evanchik MJ, Yang W. Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5648-52. Epub 2008 Aug 29. PMID:18793847 doi:10.1016/j.bmcl.2008.08.095

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OCA

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