3cjo
From Proteopedia
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[[Image:3cjo.png|left|200px]] | [[Image:3cjo.png|left|200px]] | ||
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{{STRUCTURE_3cjo| PDB=3cjo | SCENE= }} | {{STRUCTURE_3cjo| PDB=3cjo | SCENE= }} | ||
===Crystal structure of KSP in complex with inhibitor 30=== | ===Crystal structure of KSP in complex with inhibitor 30=== | ||
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{{ABSTRACT_PUBMED_18578472}} | {{ABSTRACT_PUBMED_18578472}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3cjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJO OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018578472</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Yan, Y.]] | [[Category: Yan, Y.]] | ||
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[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cell division]] | [[Category: Cell division]] | ||
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[[Category: Ksp]] | [[Category: Ksp]] | ||
[[Category: Ksp-inhibitor complex]] | [[Category: Ksp-inhibitor complex]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
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Revision as of 18:45, 7 January 2013
Crystal structure of KSP in complex with inhibitor 30
Template:ABSTRACT PUBMED 18578472
About this Structure
3cjo is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Cox CD, Coleman PJ, Breslin MJ, Whitman DB, Garbaccio RM, Fraley ME, Buser CA, Walsh ES, Hamilton K, Schaber MD, Lobell RB, Tao W, Davide JP, Diehl RE, Abrams MT, South VJ, Huber HE, Torrent M, Prueksaritanont T, Li C, Slaughter DE, Mahan E, Fernandez-Metzler C, Yan Y, Kuo LC, Kohl NE, Hartman GD. Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2- (hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer. J Med Chem. 2008 Jun 25;. PMID:18578472 doi:10.1021/jm800386y
