1xe3
From Proteopedia
(New page: 200px<br /><applet load="1xe3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xe3, resolution 2.24Å" /> '''Crystal Structure of...) |
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| - | [[Image:1xe3.jpg|left|200px]]<br /><applet load="1xe3" size=" | + | [[Image:1xe3.jpg|left|200px]]<br /><applet load="1xe3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1xe3, resolution 2.24Å" /> | caption="1xe3, resolution 2.24Å" /> | ||
'''Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis'''<br /> | '''Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Protein structures from the causative agent of anthrax (Bacillus | + | Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium. |
==About this Structure== | ==About this Structure== | ||
| - | 1XE3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] Full crystallographic information is available from [http:// | + | 1XE3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE3 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis., Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS, Acta | + | Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis., Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16511068 16511068] |
[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
[[Category: Purine-nucleoside phosphorylase]] | [[Category: Purine-nucleoside phosphorylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Blagova, E | + | [[Category: Blagova, E V.]] |
| - | [[Category: Brannigan, J | + | [[Category: Brannigan, J A.]] |
[[Category: Fogg, M.]] | [[Category: Fogg, M.]] | ||
[[Category: Grenha, R.]] | [[Category: Grenha, R.]] | ||
| - | [[Category: Levdikov, V | + | [[Category: Levdikov, V M.]] |
| - | [[Category: SPINE, Structural | + | [[Category: SPINE, Structural Proteomics in Europe.]] |
| - | [[Category: Wilkinson, A | + | [[Category: Wilkinson, A J.]] |
| - | [[Category: Wilson, K | + | [[Category: Wilson, K S.]] |
[[Category: CL]] | [[Category: CL]] | ||
[[Category: deod]] | [[Category: deod]] | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:53:48 2008'' |
Revision as of 13:53, 21 February 2008
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Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis
Overview
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
About this Structure
1XE3 is a Single protein structure of sequence from Bacillus anthracis with as ligand. Active as Purine-nucleoside phosphorylase, with EC number 2.4.2.1 Full crystallographic information is available from OCA.
Reference
Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis., Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068
Page seeded by OCA on Thu Feb 21 15:53:48 2008
Categories: Bacillus anthracis | Purine-nucleoside phosphorylase | Single protein | Blagova, E V. | Brannigan, J A. | Fogg, M. | Grenha, R. | Levdikov, V M. | SPINE, Structural Proteomics in Europe. | Wilkinson, A J. | Wilson, K S. | CL | Deod | Purine nucleoside phosphorylase | Spine | Structural genomics | Structural proteomics in europe
