1xqj
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Maspin, a member of the serpin superfamily, has tumor suppressing activity | + | Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Al-Ayyoubi, M.]] | [[Category: Al-Ayyoubi, M.]] | ||
| - | [[Category: Gettins, P | + | [[Category: Gettins, P G.]] |
[[Category: Volz, K.]] | [[Category: Volz, K.]] | ||
[[Category: maspin]] | [[Category: maspin]] | ||
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[[Category: tumor suppression]] | [[Category: tumor suppression]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:57:39 2008'' |
Revision as of 13:57, 21 February 2008
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3.10 A Crystal structure of maspin, space group I 4 2 2
Overview
Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors.
About this Structure
1XQJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained., Al-Ayyoubi M, Gettins PG, Volz K, J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:15501821
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