1xs7
From Proteopedia
(New page: 200px<br /> <applet load="1xs7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xs7, resolution 2.8Å" /> '''Crystal Structure of...) |
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| - | [[Image:1xs7.gif|left|200px]]<br /> | + | [[Image:1xs7.gif|left|200px]]<br /><applet load="1xs7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1xs7" size=" | + | |
caption="1xs7, resolution 2.8Å" /> | caption="1xs7, resolution 2.8Å" /> | ||
'''Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).'''<br /> | '''Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A series of novel macrocyclic amide-urethanes was designed and synthesized | + | A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure of our lead inhibitor (1, OM99-2 with eight residues) bound to memapsin 2. Ring size and substituent effects have been investigated. Cycloamide-urethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against human brain memapsin 2 (beta-secretase). |
==About this Structure== | ==About this Structure== | ||
| - | 1XS7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MMI as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http:// | + | 1XS7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MMI:'>MMI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XS7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: memapsin2]] | [[Category: memapsin2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:58:07 2008'' |
Revision as of 13:58, 21 February 2008
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Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).
Overview
A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure of our lead inhibitor (1, OM99-2 with eight residues) bound to memapsin 2. Ring size and substituent effects have been investigated. Cycloamide-urethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against human brain memapsin 2 (beta-secretase).
About this Structure
1XS7 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.
Reference
Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase)., Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J, Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. PMID:15582402
Page seeded by OCA on Thu Feb 21 15:58:07 2008
Categories: Homo sapiens | Memapsin 2 | Single protein | Bilcer, G. | DeZutter, C. | Devasamudram, T. | Ghosh, A. | Hong, L. | Koelsch, G. | Tang, J. | Weerasena, V. | Xu, X. | MMI | Acid protease | Alzheimer's disease | Asp2 | Aspartic protease | Bace | Beta secretase | Crystallography | Drug design | Memapsin2
