1xud
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | The paradigm for matrix metalloprotease inhibition combines active site | + | The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Engel, C | + | [[Category: Engel, C K.]] |
| - | [[Category: Wendt, K | + | [[Category: Wendt, K U.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: PB4]] | [[Category: PB4]] | ||
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[[Category: non-zinc binding inhibitor]] | [[Category: non-zinc binding inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:58:44 2008'' |
Revision as of 13:58, 21 February 2008
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Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor
Overview
The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.
About this Structure
1XUD is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640
Page seeded by OCA on Thu Feb 21 15:58:44 2008
