3c4e

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Revision as of 21:08, 7 January 2013

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Template:STRUCTURE 3c4e

Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole

Template:ABSTRACT PUBMED 18287029

About this Structure

3c4e is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KS, Fong D, Zhu YL, Marimuthu A, Nguyen H, Lam B, Liu J, Cheung I, Rice J, Suzuki Y, Luu C, Settachatgul C, Shellooe R, Cantwell J, Kim SH, Schlessinger J, Zhang KY, West BL, Powell B, Habets G, Zhang C, Ibrahim PN, Hirth P, Artis DR, Herlyn M, Bollag G. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3041-6. Epub 2008 Feb 19. PMID:18287029