1xwv
From Proteopedia
(New page: 200px<br /><applet load="1xwv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xwv, resolution 1.83Å" /> '''Structure of the hou...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1xwv.gif|left|200px]]<br /><applet load="1xwv" size=" | + | [[Image:1xwv.gif|left|200px]]<br /><applet load="1xwv" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1xwv, resolution 1.83Å" /> | caption="1xwv, resolution 1.83Å" /> | ||
'''Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity'''<br /> | '''Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The X-ray structure of the group 2 major allergen from Dermatophagoides | + | The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes. |
==About this Structure== | ==About this Structure== | ||
| - | 1XWV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae] with PE3 and XPE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1XWV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae] with <scene name='pdbligand=PE3:'>PE3</scene> and <scene name='pdbligand=XPE:'>XPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWV OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Bolwig, C.]] | [[Category: Bolwig, C.]] | ||
[[Category: Gajhede, M.]] | [[Category: Gajhede, M.]] | ||
| - | [[Category: Johannessen, B | + | [[Category: Johannessen, B R.]] |
| - | [[Category: Kastrup, J | + | [[Category: Kastrup, J S.]] |
[[Category: Kristensen, O.]] | [[Category: Kristensen, O.]] | ||
| - | [[Category: Larsen, J | + | [[Category: Larsen, J N.]] |
[[Category: Lund, K.]] | [[Category: Lund, K.]] | ||
| - | [[Category: Skov, L | + | [[Category: Skov, L K.]] |
[[Category: Spangfort, M.]] | [[Category: Spangfort, M.]] | ||
[[Category: PE3]] | [[Category: PE3]] | ||
| Line 26: | Line 26: | ||
[[Category: beta sheets]] | [[Category: beta sheets]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:59:29 2008'' |
Revision as of 13:59, 21 February 2008
|
Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity
Overview
The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.
About this Structure
1XWV is a Single protein structure of sequence from Dermatophagoides farinae with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity., Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M, FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415
Page seeded by OCA on Thu Feb 21 15:59:29 2008
