1y4m
From Proteopedia
(New page: 200px<br /> <applet load="1y4m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y4m, resolution 1.60Å" /> '''Crystal structure o...) |
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| - | [[Image:1y4m.gif|left|200px]]<br /> | + | [[Image:1y4m.gif|left|200px]]<br /><applet load="1y4m" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1y4m" size=" | + | |
caption="1y4m, resolution 1.60Å" /> | caption="1y4m, resolution 1.60Å" /> | ||
'''Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)'''<br /> | '''Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | HERV-FRD is a human endogenous retrovirus that entered the human genome 40 | + | HERV-FRD is a human endogenous retrovirus that entered the human genome 40 million years ago. Its envelope gene, syncytin-2, was diverted by an ancestral host most probably because of its fusogenic property, for a role in placenta morphogenesis. It was maintained in a functional state in all primate branches as a bona fide cellular gene, submitted to a very low mutation rate as compared to infectious retrovirus genomes. The structure of the syncytin-2 protein thus provides a good insight into that of the oldest mammalian retroviral envelope. Here, we report the crystal structure of a central fragment of its "fossil" ectodomain, allowing a remarkable superposition with the structures of the corresponding domains of present-day infectious retroviruses, in spite of a more than 60% divergent sequence. These results suggest the existence of a unique structural solution selected by these proteins for their fusogenic function. |
==About this Structure== | ==About this Structure== | ||
| - | 1Y4M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1Y4M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4M OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Letzelter, C.]] | [[Category: Letzelter, C.]] | ||
[[Category: Renard, M.]] | [[Category: Renard, M.]] | ||
| - | [[Category: Rey, F | + | [[Category: Rey, F A.]] |
| - | [[Category: Varela, P | + | [[Category: Varela, P F.]] |
[[Category: CL]] | [[Category: CL]] | ||
[[Category: coat protein]] | [[Category: coat protein]] | ||
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[[Category: membrane fusion]] | [[Category: membrane fusion]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:01:44 2008'' |
Revision as of 14:01, 21 February 2008
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Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)
Overview
HERV-FRD is a human endogenous retrovirus that entered the human genome 40 million years ago. Its envelope gene, syncytin-2, was diverted by an ancestral host most probably because of its fusogenic property, for a role in placenta morphogenesis. It was maintained in a functional state in all primate branches as a bona fide cellular gene, submitted to a very low mutation rate as compared to infectious retrovirus genomes. The structure of the syncytin-2 protein thus provides a good insight into that of the oldest mammalian retroviral envelope. Here, we report the crystal structure of a central fragment of its "fossil" ectodomain, allowing a remarkable superposition with the structures of the corresponding domains of present-day infectious retroviruses, in spite of a more than 60% divergent sequence. These results suggest the existence of a unique structural solution selected by these proteins for their fusogenic function.
About this Structure
1Y4M is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates., Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T, J Mol Biol. 2005 Oct 7;352(5):1029-34. PMID:16140326
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