This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2qy0
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2qy0.png|left|200px]] | [[Image:2qy0.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2qy0", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2qy0| PDB=2qy0 | SCENE= }} | {{STRUCTURE_2qy0| PDB=2qy0 | SCENE= }} | ||
===Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts=== | ===Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_17996945}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 17996945 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_17996945}} | {{ABSTRACT_PUBMED_17996945}} | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: C1r/C1s deficiency, combined OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=216950 216950]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2qy0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017996945</ref><references group="xtra"/> |
[[Category: Complement subcomponent C1r]] | [[Category: Complement subcomponent C1r]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 49: | Line 34: | ||
[[Category: Innate immunity]] | [[Category: Innate immunity]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Sushi]] | [[Category: Sushi]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:34:44 2009'' | ||
Revision as of 22:39, 7 January 2013
Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts
Template:ABSTRACT PUBMED 17996945
About this Structure
2qy0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kardos J, Harmat V, Pallo A, Barabas O, Szilagyi K, Graf L, Naray-Szabo G, Goto Y, Zavodszky P, Gal P. Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r. Mol Immunol. 2008 Mar;45(6):1752-60. Epub 2007 Nov 9. PMID:17996945 doi:10.1016/j.molimm.2007.09.031
Categories: Complement subcomponent C1r | Homo sapiens | Barabas, O. | Gal, P. | Goto, Y. | Graf, L. | Harmat, V. | Kardos, J. | Naray-Szabo, G. | Pallo, A. | Szilagyi, K. | Zavodszky, P. | Beta barrel | Complement | Complement pathway | Egf-like domain | Glycoprotein | Hydrolase | Hydroxylation | Immune response | Innate immunity | Phosphorylation | Serine protease | Sushi
