1ybi
From Proteopedia
(New page: 200px<br /><applet load="1ybi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ybi, resolution 1.50Å" /> '''Crystal structure of...) |
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| - | [[Image:1ybi.gif|left|200px]]<br /><applet load="1ybi" size=" | + | [[Image:1ybi.gif|left|200px]]<br /><applet load="1ybi" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ybi, resolution 1.50Å" /> | caption="1ybi, resolution 1.50Å" /> | ||
'''Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A'''<br /> | '''Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The hemagglutinating protein HA33 from Clostridium botulinum is associated | + | The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 A resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold. |
==About this Structure== | ==About this Structure== | ||
| - | 1YBI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http:// | + | 1YBI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Arndt, J | + | [[Category: Arndt, J W.]] |
[[Category: Gu, J.]] | [[Category: Gu, J.]] | ||
[[Category: Hanson, M.]] | [[Category: Hanson, M.]] | ||
[[Category: Jaroszewski, L.]] | [[Category: Jaroszewski, L.]] | ||
| - | [[Category: Lebeda, F | + | [[Category: Lebeda, F J.]] |
[[Category: Schwarzenbacher, R.]] | [[Category: Schwarzenbacher, R.]] | ||
| - | [[Category: Stevens, R | + | [[Category: Stevens, R C.]] |
[[Category: beta-trefoil]] | [[Category: beta-trefoil]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:03:38 2008'' |
Revision as of 14:03, 21 February 2008
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Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A
Overview
The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 A resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold.
About this Structure
1YBI is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
Reference
The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex., Arndt JW, Gu J, Jaroszewski L, Schwarzenbacher R, Hanson MA, Lebeda FJ, Stevens RC, J Mol Biol. 2005 Mar 4;346(4):1083-93. Epub 2005 Jan 20. PMID:15701519
Page seeded by OCA on Thu Feb 21 16:03:38 2008
