1ygz
From Proteopedia
(New page: 200px<br /><applet load="1ygz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ygz, resolution 2.6Å" /> '''Crystal Structure of ...) |
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| - | [[Image:1ygz.jpg|left|200px]]<br /><applet load="1ygz" size=" | + | [[Image:1ygz.jpg|left|200px]]<br /><applet load="1ygz" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ygz, resolution 2.6Å" /> | caption="1ygz, resolution 2.6Å" /> | ||
'''Crystal Structure of Inorganic Pyrophosphatase from Helicobacter pylori'''<br /> | '''Crystal Structure of Inorganic Pyrophosphatase from Helicobacter pylori'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Inorganic pyrophosphatase (PPase) is a ubiquitous cytosolic enzyme which | + | Inorganic pyrophosphatase (PPase) is a ubiquitous cytosolic enzyme which catalyzes the hydrolysis of inorganic pyrophosphate (PPi) to orthophosphate (Pi). The crystal structure of inorganic pyrophosphatase from Helicobacter pylori (H-PPase) has been solved by MAD and refined to an R factor of 20.6% at 2.6 A resolution. The crystallographic asymmetric unit contains a homohexameric H-PPase arranged as a dimer of trimers. While most of the structural elements of PPases are highly conserved in H-PPase, some unique structural features are localized in the flexible loops near the active site, suggesting that the structural flexibility of these loops is required for the catalytic efficiency of PPase. |
==About this Structure== | ==About this Structure== | ||
| - | 1YGZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Active as [http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] Full crystallographic information is available from [http:// | + | 1YGZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Active as [http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YGZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Inorganic diphosphatase]] | [[Category: Inorganic diphosphatase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Hwang, H | + | [[Category: Hwang, H Y.]] |
| - | [[Category: Kim, D | + | [[Category: Kim, D Y.]] |
| - | [[Category: Kim, K | + | [[Category: Kim, K K.]] |
| - | [[Category: Kim, S | + | [[Category: Kim, S T.]] |
| - | [[Category: Lokanath, N | + | [[Category: Lokanath, N K.]] |
| - | [[Category: Park, H | + | [[Category: Park, H J.]] |
| - | [[Category: Suh, S | + | [[Category: Suh, S W.]] |
| - | [[Category: Wu, C | + | [[Category: Wu, C A.]] |
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:11 2008'' |
Revision as of 14:05, 21 February 2008
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Crystal Structure of Inorganic Pyrophosphatase from Helicobacter pylori
Overview
Inorganic pyrophosphatase (PPase) is a ubiquitous cytosolic enzyme which catalyzes the hydrolysis of inorganic pyrophosphate (PPi) to orthophosphate (Pi). The crystal structure of inorganic pyrophosphatase from Helicobacter pylori (H-PPase) has been solved by MAD and refined to an R factor of 20.6% at 2.6 A resolution. The crystallographic asymmetric unit contains a homohexameric H-PPase arranged as a dimer of trimers. While most of the structural elements of PPases are highly conserved in H-PPase, some unique structural features are localized in the flexible loops near the active site, suggesting that the structural flexibility of these loops is required for the catalytic efficiency of PPase.
About this Structure
1YGZ is a Single protein structure of sequence from Helicobacter pylori. Active as Inorganic diphosphatase, with EC number 3.6.1.1 Full crystallographic information is available from OCA.
Reference
Structure of inorganic pyrophosphatase from Helicobacter pylori., Wu CA, Lokanath NK, Kim DY, Park HJ, Hwang HY, Kim ST, Suh SW, Kim KK, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1459-64. Epub 2005, Oct 19. PMID:16239722
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