1yho
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1yho" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yho" /> '''Solution structure of human dihydrofolate r...) |
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'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''<br /> | '''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NDP and TRR as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http:// | + | 1YHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=TRR:'>TRR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Birdsall, B.]] | [[Category: Birdsall, B.]] | ||
| - | [[Category: Polshakov, V | + | [[Category: Polshakov, V I.]] |
[[Category: NDP]] | [[Category: NDP]] | ||
[[Category: TRR]] | [[Category: TRR]] | ||
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[[Category: inhibitor/enzyme complex]] | [[Category: inhibitor/enzyme complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:28 2008'' |
Revision as of 14:05, 21 February 2008
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Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Disease
Known disease associated with this structure: Anemia, megaloblastic, due to DHFR deficiency (1) OMIM:[126060]
About this Structure
1YHO is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Dihydrofolate reductase, with EC number 1.5.1.3 Full crystallographic information is available from OCA.
Reference
Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:16222560
Page seeded by OCA on Thu Feb 21 16:05:28 2008
