1yi8
From Proteopedia
(New page: 200px<br /><applet load="1yi8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yi8, resolution 2.1Å" /> '''Crystal structure of ...) |
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| - | [[Image:1yi8.gif|left|200px]]<br /><applet load="1yi8" size=" | + | [[Image:1yi8.gif|left|200px]]<br /><applet load="1yi8" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1yi8, resolution 2.1Å" /> | caption="1yi8, resolution 2.1Å" /> | ||
'''Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp'''<br /> | '''Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found | + | The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids. |
==About this Structure== | ==About this Structure== | ||
| - | 1YI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1] with TRP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1YI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1] with <scene name='pdbligand=TRP:'>TRP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YI8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Deinococcus radiodurans r1]] | [[Category: Deinococcus radiodurans r1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Buddha, M | + | [[Category: Buddha, M R.]] |
| - | [[Category: Crane, B | + | [[Category: Crane, B R.]] |
[[Category: TRP]] | [[Category: TRP]] | ||
[[Category: auxiliary tryptophanyl trna synthetase]] | [[Category: auxiliary tryptophanyl trna synthetase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:43 2008'' |
Revision as of 14:05, 21 February 2008
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Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp
Overview
The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids.
About this Structure
1YI8 is a Single protein structure of sequence from Deinococcus radiodurans r1 with as ligand. Full crystallographic information is available from OCA.
Reference
Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:15723076
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