1yiv
From Proteopedia
(New page: 200px<br /><applet load="1yiv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yiv, resolution 2.10Å" /> '''Structure of myelin ...) |
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| - | [[Image:1yiv.gif|left|200px]]<br /><applet load="1yiv" size=" | + | [[Image:1yiv.gif|left|200px]]<br /><applet load="1yiv" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1yiv, resolution 2.10Å" /> | caption="1yiv, resolution 2.10Å" /> | ||
'''Structure of myelin P2 protein from Equine spinal cord'''<br /> | '''Structure of myelin P2 protein from Equine spinal cord'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Equine P2 protein has been isolated from horse spinal cord and its | + | Equine P2 protein has been isolated from horse spinal cord and its structure determined to 2.1 A. Since equine myelin is a viable alternative to bovine tissue for large-scale preparations, characterization of the proteins from equine spinal cord myelin has been initiated. There is an unusually high amount of P2 protein in equine CNS myelin compared with other species. The structure was determined by molecular replacement and subsequently refined to an R value of 0.187 (Rfree=0.233). The structure contains a molecule of the detergent LDAO and HEPES buffer in the binding cavity and is otherwise analogous to other cellular retinol-binding proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1YIV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with EPE and LDA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1YIV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with <scene name='pdbligand=EPE:'>EPE</scene> and <scene name='pdbligand=LDA:'>LDA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Equus caballus]] | [[Category: Equus caballus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Freer, A | + | [[Category: Freer, A A.]] |
| - | [[Category: Grifiths, I | + | [[Category: Grifiths, I R.]] |
| - | [[Category: Hunter, D | + | [[Category: Hunter, D J.B.]] |
[[Category: MacMaster, R.]] | [[Category: MacMaster, R.]] | ||
[[Category: Riboldi-Tunnicliffe, A.]] | [[Category: Riboldi-Tunnicliffe, A.]] | ||
| - | [[Category: Rozak, A | + | [[Category: Rozak, A W.]] |
[[Category: EPE]] | [[Category: EPE]] | ||
[[Category: LDA]] | [[Category: LDA]] | ||
[[Category: p2 protein]] | [[Category: p2 protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:46 2008'' |
Revision as of 14:05, 21 February 2008
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Structure of myelin P2 protein from Equine spinal cord
Overview
Equine P2 protein has been isolated from horse spinal cord and its structure determined to 2.1 A. Since equine myelin is a viable alternative to bovine tissue for large-scale preparations, characterization of the proteins from equine spinal cord myelin has been initiated. There is an unusually high amount of P2 protein in equine CNS myelin compared with other species. The structure was determined by molecular replacement and subsequently refined to an R value of 0.187 (Rfree=0.233). The structure contains a molecule of the detergent LDAO and HEPES buffer in the binding cavity and is otherwise analogous to other cellular retinol-binding proteins.
About this Structure
1YIV is a Protein complex structure of sequences from Equus caballus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of myelin P2 protein from equine spinal cord., Hunter DJ, Macmaster R, Roszak AW, Riboldi-Tunnicliffe A, Griffiths IR, Freer AA, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1067-71. Epub 2005, Jul 20. PMID:16041071
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