3efk
From Proteopedia
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{{STRUCTURE_3efk| PDB=3efk | SCENE= }} | {{STRUCTURE_3efk| PDB=3efk | SCENE= }} | ||
===Structure of c-Met with pyrimidone inhibitor 50=== | ===Structure of c-Met with pyrimidone inhibitor 50=== | ||
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{{ABSTRACT_PUBMED_18763753}} | {{ABSTRACT_PUBMED_18763753}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3efk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFK OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018763753</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
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[[Category: Dussault, I.]] | [[Category: Dussault, I.]] | ||
[[Category: Whittington, D.]] | [[Category: Whittington, D.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: C-met]] | [[Category: C-met]] | ||
| - | [[Category: Chromosomal rearrangement]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Proto-oncogene]] | [[Category: Proto-oncogene]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:42:28 2009'' | ||
Revision as of 08:52, 9 January 2013
Structure of c-Met with pyrimidone inhibitor 50
Template:ABSTRACT PUBMED 18763753
About this Structure
3efk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- D'Angelo ND, Bellon SF, Booker SK, Cheng Y, Coxon A, Dominguez C, Fellows I, Hoffman D, Hungate R, Kaplan-Lefko P, Lee MR, Li C, Liu L, Rainbeau E, Reider PJ, Rex K, Siegmund A, Sun Y, Tasker AS, Xi N, Xu S, Yang Y, Zhang Y, Burgess TL, Dussault I, Kim TS. Design, synthesis, and biological evaluation of potent c-Met inhibitors. J Med Chem. 2008 Sep 25;51(18):5766-79. PMID:18763753 doi:10.1021/jm8006189
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Angelo, N D. | Bellon, S F. | Dussault, I. | Whittington, D. | Atp-binding | C-met | Disease mutation | Glycoprotein | Kinase | Kinase inhibitor pyrimidone | Membrane | Nucleotide-binding | Phosphoprotein | Proto-oncogene | Receptor | Transferase | Transmembrane | Tyrosine-protein kinase
