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1ykb

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(New page: 200px<br /> <applet load="1ykb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ykb, resolution 2.60&Aring;" /> '''Crystal Structure o...)
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<applet load="1ykb" size="450" color="white" frame="true" align="right" spinBox="true"
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'''Crystal Structure of Insect Cell Expressed IL-22'''<br />
'''Crystal Structure of Insect Cell Expressed IL-22'''<br />
==Overview==
==Overview==
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The crystal structure of interleukin-22 expressed in Drosophila, melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution., IL-22(Dm) crystals contain six molecules in the asymmetric unit., Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in, Escherichia coli) structures reveals that N-linked glycosylation causes, only minor structural changes to the cytokine. However, 1-4 A main-chain, differences are observed between the six IL-22(Dm) monomers at regions, corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of, the carbohydrate and the conformational variation of IL22(Dm) provide new, insights into IL-22 receptor recognition.
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The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.
==About this Structure==
==About this Structure==
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1YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].
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1YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].
==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Logsdon, N.J.]]
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[[Category: Logsdon, N J.]]
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[[Category: Walter, M.R.]]
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[[Category: Walter, M R.]]
[[Category: Xu, T.]]
[[Category: Xu, T.]]
[[Category: NAG]]
[[Category: NAG]]
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[[Category: interleukin]]
[[Category: interleukin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:21:19 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:18 2008''

Revision as of 14:06, 21 February 2008

Image:1ykb.gif

1ykb, resolution 2.60Å

Drag the structure with the mouse to rotate

Crystal Structure of Insect Cell Expressed IL-22

Overview

The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.

About this Structure

1YKB is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

Reference

Structure of insect-cell-derived IL-22., Xu T, Logsdon NJ, Walter MR, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417

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