1yow
From Proteopedia
(New page: 200px<br /> <applet load="1yow" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yow, resolution 3.0Å" /> '''human Steroidogenic ...) |
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| - | [[Image:1yow.gif|left|200px]]<br /> | + | [[Image:1yow.gif|left|200px]]<br /><applet load="1yow" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1yow" size=" | + | |
caption="1yow, resolution 3.0Å" /> | caption="1yow, resolution 3.0Å" /> | ||
'''human Steroidogenic Factor 1 LBD with bound Co-factor Peptide'''<br /> | '''human Steroidogenic Factor 1 LBD with bound Co-factor Peptide'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Vertebrate members of the nuclear receptor NR5A subfamily, which includes | + | Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors. |
==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Adrenocortical insufficiency without ovarian defect OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=184757 184757]], Sex reversal, XY, with adrenal failure OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=184757 184757]] | + | Known diseases associated with this structure: Adrenocortical insufficiency without ovarian defect OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=184757 184757]], Disorder of sex development, 46XY OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=184757 184757]], Sex reversal, XY, with/without adrenal failure OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=184757 184757]] |
==About this Structure== | ==About this Structure== | ||
| - | 1YOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with P0E as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1YOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=P0E:'>P0E</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOW OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bynum, J | + | [[Category: Bynum, J M.]] |
| - | [[Category: Guy, R | + | [[Category: Guy, R K.]] |
| - | [[Category: Ingraham, H | + | [[Category: Ingraham, H A.]] |
[[Category: Juzumiene, D.]] | [[Category: Juzumiene, D.]] | ||
| - | [[Category: Krylova, I | + | [[Category: Krylova, I N.]] |
[[Category: Lebedeva, L.]] | [[Category: Lebedeva, L.]] | ||
| - | [[Category: MacKay, J | + | [[Category: MacKay, J A.]] |
| - | [[Category: Madauss, K | + | [[Category: Madauss, K P.]] |
[[Category: Montana, V.]] | [[Category: Montana, V.]] | ||
[[Category: Moore, J.]] | [[Category: Moore, J.]] | ||
| - | [[Category: Sablin, E | + | [[Category: Sablin, E P.]] |
[[Category: Suzawa, M.]] | [[Category: Suzawa, M.]] | ||
| - | [[Category: Thornton, J | + | [[Category: Thornton, J W.]] |
| - | [[Category: Waitt, G | + | [[Category: Waitt, G M.]] |
| - | [[Category: Williams, J | + | [[Category: Williams, J D.]] |
| - | [[Category: Williams, S | + | [[Category: Williams, S P.]] |
| - | [[Category: Willson, T | + | [[Category: Willson, T M.]] |
| - | [[Category: Xu, R | + | [[Category: Xu, R X.]] |
[[Category: P0E]] | [[Category: P0E]] | ||
[[Category: phosphatidyl ethanolamine]] | [[Category: phosphatidyl ethanolamine]] | ||
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[[Category: steroidogenic factor 1]] | [[Category: steroidogenic factor 1]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:07:34 2008'' |
Revision as of 14:07, 21 February 2008
|
human Steroidogenic Factor 1 LBD with bound Co-factor Peptide
Contents |
Overview
Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.
Disease
Known diseases associated with this structure: Adrenocortical insufficiency without ovarian defect OMIM:[184757], Disorder of sex development, 46XY OMIM:[184757], Sex reversal, XY, with/without adrenal failure OMIM:[184757]
About this Structure
1YOW is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1., Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA, Cell. 2005 Feb 11;120(3):343-55. PMID:15707893
Page seeded by OCA on Thu Feb 21 16:07:34 2008
Categories: Homo sapiens | Single protein | Bynum, J M. | Guy, R K. | Ingraham, H A. | Juzumiene, D. | Krylova, I N. | Lebedeva, L. | MacKay, J A. | Madauss, K P. | Montana, V. | Moore, J. | Sablin, E P. | Suzawa, M. | Thornton, J W. | Waitt, G M. | Williams, J D. | Williams, S P. | Willson, T M. | Xu, R X. | P0E | Phosphatidyl ethanolamine | Phosphatidyl glycerol | Phospholipid | Sf1 | Steroidogenic factor 1
