1ysv

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(New page: 200px<br /><applet load="1ysv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ysv" /> '''Solution structure of the central region of ...)
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[[Image:1ysv.gif|left|200px]]<br /><applet load="1ysv" size="350" color="white" frame="true" align="right" spinBox="true"
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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''<br />
'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''<br />
==Overview==
==Overview==
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Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific, conversion of adenosine to inosine in primary mRNA transcripts, thereby, affecting coding potential of mature mRNAs. Structural determinants that, define the adenosine moieties for specific ADARs-mediated deaminations are, currently unknown. We report the solution structure of the central region, of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding, the subunit B of the glutamate receptor (R/G site). The structure reveals, that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts, a novel fold. The fold is stabilized by a complex interplay of hydrogen, bonds and stacking interactions. We propose that this new pentaloop, structure is an important determinant of the R/G site recognition by, ADAR2.
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Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
==About this Structure==
==About this Structure==
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1YSV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
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1YSV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
==Reference==
==Reference==
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15840813 15840813]
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15840813 15840813]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Allain, F.H.]]
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[[Category: Allain, F H.]]
[[Category: Stefl, R.]]
[[Category: Stefl, R.]]
[[Category: adar2]]
[[Category: adar2]]
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[[Category: structure]]
[[Category: structure]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 04:33:27 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:08:44 2008''

Revision as of 14:08, 21 February 2008

Image:1ysv.gif

1ysv

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Solution structure of the central region of the human GluR-B R/G pre-mRNA

Overview

Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.

About this Structure

1YSV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813

Page seeded by OCA on Thu Feb 21 16:08:44 2008

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