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1yvs
From Proteopedia
(New page: 200px<br /><applet load="1yvs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yvs, resolution 2.2Å" /> '''TRIMERIC DOMAIN SWAPP...) |
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| - | [[Image:1yvs.jpg|left|200px]]<br /><applet load="1yvs" size=" | + | [[Image:1yvs.jpg|left|200px]]<br /><applet load="1yvs" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1yvs, resolution 2.2Å" /> | caption="1yvs, resolution 2.2Å" /> | ||
'''TRIMERIC DOMAIN SWAPPED BARNASE'''<br /> | '''TRIMERIC DOMAIN SWAPPED BARNASE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of a trimeric domain-swapped form of barnase (EC 3.1. 27.3) | + | The structure of a trimeric domain-swapped form of barnase (EC 3.1. 27.3) was determined by x-ray crystallography at a resolution of 2.2 A from crystals of space group R32. Residues 1-36 of one molecule associate with residues 41-110 from another molecule related through threefold symmetry. The resulting cyclic trimer contains three protein folds that are very similar to those in monomeric barnase. Both swapped domains contain a nucleation site for folding. The formation of a domain-swapped trimer is consistent with the description of the folding process of monomeric barnase as the formation and subsequent association of two foldons. |
==About this Structure== | ==About this Structure== | ||
| - | 1YVS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1YVS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: trimer]] | [[Category: trimer]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:40 2008'' |
Revision as of 14:09, 21 February 2008
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TRIMERIC DOMAIN SWAPPED BARNASE
Overview
The structure of a trimeric domain-swapped form of barnase (EC 3.1. 27.3) was determined by x-ray crystallography at a resolution of 2.2 A from crystals of space group R32. Residues 1-36 of one molecule associate with residues 41-110 from another molecule related through threefold symmetry. The resulting cyclic trimer contains three protein folds that are very similar to those in monomeric barnase. Both swapped domains contain a nucleation site for folding. The formation of a domain-swapped trimer is consistent with the description of the folding process of monomeric barnase as the formation and subsequent association of two foldons.
About this Structure
1YVS is a Single protein structure of sequence from Bacillus amyloliquefaciens with as ligand. Full crystallographic information is available from OCA.
Reference
Trimeric domain-swapped barnase., Zegers I, Deswarte J, Wyns L, Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):818-22. PMID:9927651
Page seeded by OCA on Thu Feb 21 16:09:40 2008
