4e4q

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-	'''Unreleased structure'''	+	[[Image:4e4q.jpg|left|200px]]
-	The entry 4e4q is ON HOLD until Paper Publication	+	{{STRUCTURE_4e4q| PDB=4e4q | SCENE= }}
-	Authors: Pochetti, G., Montanari, R., Loiodice, F., Fracchiolla, G., Laghezza, A., Carbonara, G., Piemontese, L., Lavecchia, A., Novellino, E.	+	===Crystal structure of PPARgamma with the ligand FS214===
-	Description: Crystal structure of PPARgamma with the ligand FS214	+	{{ABSTRACT_PUBMED_23171045}}
		+
		+	==About this Structure==
		+	[[4e4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E4Q OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019053776</ref><ref group="xtra">PMID:018263587</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Carbonara, G.]]
		+	[[Category: Fracchiolla, G.]]
		+	[[Category: Laghezza, A.]]
		+	[[Category: Lavecchia, A.]]
		+	[[Category: Loiodice, F.]]
		+	[[Category: Montanari, R.]]
		+	[[Category: Novellino, E.]]
		+	[[Category: Piemontese, L.]]
		+	[[Category: Pochetti, G.]]
		+	[[Category: Bundle of alpha-helices and a small four-stranded beta-sheet]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]

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Revision as of 11:36, 23 January 2013

Template:STRUCTURE 4e4q

Crystal structure of PPARgamma with the ligand FS214

Template:ABSTRACT PUBMED 23171045

About this Structure

4e4q is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776 doi:10.1021/jm800733h
• Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL. T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties. J Biol Chem. 2008 Apr 4;283(14):9168-76. Epub 2008 Feb 7. PMID:18263587 doi:10.1074/jbc.M800104200