1z3f
From Proteopedia
(New page: 200px<br /><applet load="1z3f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z3f, resolution 1.50Å" /> '''Structure of ellipti...) |
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| - | [[Image:1z3f.gif|left|200px]]<br /><applet load="1z3f" size=" | + | [[Image:1z3f.gif|left|200px]]<br /><applet load="1z3f" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1z3f, resolution 1.50Å" /> | caption="1z3f, resolution 1.50Å" /> | ||
'''Structure of ellipticine in complex with a 6-bp DNA'''<br /> | '''Structure of ellipticine in complex with a 6-bp DNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Ellipticine is a natural plant product that has been found to be a | + | Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA. |
==About this Structure== | ==About this Structure== | ||
| - | 1Z3F is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with EL and CO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1Z3F is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=EL:'>EL</scene> and <scene name='pdbligand=CO:'>CO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA]. |
==Reference== | ==Reference== | ||
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[[Category: intercalator]] | [[Category: intercalator]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:11:44 2008'' |
Revision as of 14:11, 21 February 2008
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Structure of ellipticine in complex with a 6-bp DNA
Overview
Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.
About this Structure
1Z3F is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:15983425
Page seeded by OCA on Thu Feb 21 16:11:44 2008
Categories: Protein complex | Aymami, J. | Canals, A. | Coll, M. | Purciolas, M. | CO | EL | Anticancer | Dna binding | Drug design | Ellipticine | Intercalator
