1z58
From Proteopedia
(New page: 200px<br /><applet load="1z58" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z58, resolution 3.8Å" /> '''Crystal structure of ...) |
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| - | [[Image:1z58.gif|left|200px]]<br /><applet load="1z58" size=" | + | [[Image:1z58.gif|left|200px]]<br /><applet load="1z58" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1z58, resolution 3.8Å" /> | caption="1z58, resolution 3.8Å" /> | ||
'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''<br /> | '''Crystal structure of a complex of the ribosome large subunit with rapamycin'''<br /> | ||
==Overview== | ==Overview== | ||
| - | RNA protection experiments and the crystal structure of a complex of the | + | RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1Z58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with RAP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1Z58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=RAP:'>RAP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tunnel]] | [[Category: tunnel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:13 2008'' |
Revision as of 14:12, 21 February 2008
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Crystal structure of a complex of the ribosome large subunit with rapamycin
Overview
RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.
About this Structure
1Z58 is a Single protein structure of sequence from Deinococcus radiodurans with as ligand. Full crystallographic information is available from OCA.
Reference
A crevice adjoining the ribosome tunnel: hints for cotranslational folding., Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:15943964
Page seeded by OCA on Thu Feb 21 16:12:13 2008
Categories: Deinococcus radiodurans | Single protein | Amit, M. | Baram, D. | Bashan, A. | Berisio, R. | Harms, J. | Yonath, A. | RAP | Polyketyde | Ribosome | Tunnel
