1z5l

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(New page: 200px<br /><applet load="1z5l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z5l, resolution 2.20&Aring;" /> '''Structure of a highl...)
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[[Image:1z5l.gif|left|200px]]<br /><applet load="1z5l" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1z5l.gif|left|200px]]<br /><applet load="1z5l" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1z5l, resolution 2.20&Aring;" />
caption="1z5l, resolution 2.20&Aring;" />
'''Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D'''<br />
'''Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D'''<br />
==Overview==
==Overview==
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Natural killer T cells express a conserved, semi-invariant alphabeta T, cell receptor that has specificity for self glycosphingolipids and, microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d, molecules. Here we report the crystal structure of CD1d in complex with a, short-chain synthetic variant of alpha-galactosylceramide at a resolution, of 2.2 A. This structure elucidates the basis for the high specificity of, these microbial ligands and explains the restriction of the alpha-linkage, as a unique pathogen-specific pattern-recognition motif. Comparison of the, binding of altered lipid ligands to CD1d and T cell receptors suggested, that the differential T helper type 1-like and T helper type 2-like, properties of natural killer T cells may originate largely from, differences in their 'loading' in different cell types and hence in their, tissue distribution in vivo.
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Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.
==About this Structure==
==About this Structure==
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1Z5L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG, PBS and R16 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA].
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1Z5L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=PBS:'>PBS</scene> and <scene name='pdbligand=R16:'>R16</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA].
==Reference==
==Reference==
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[[Category: Cantu, C.]]
[[Category: Cantu, C.]]
[[Category: Mattner, J.]]
[[Category: Mattner, J.]]
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[[Category: Savage, P.B.]]
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[[Category: Savage, P B.]]
[[Category: Teyton, L.]]
[[Category: Teyton, L.]]
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[[Category: Wilson, I.A.]]
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[[Category: Wilson, I A.]]
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[[Category: Zajonc, D.M.]]
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[[Category: Zajonc, D M.]]
[[Category: Zhou, D.]]
[[Category: Zhou, D.]]
[[Category: NAG]]
[[Category: NAG]]
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[[Category: mhc fold]]
[[Category: mhc fold]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:15:05 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:16 2008''

Revision as of 14:12, 21 February 2008

Image:1z5l.gif

1z5l, resolution 2.20Å

Drag the structure with the mouse to rotate

Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D

Overview

Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.

About this Structure

1Z5L is a Protein complex structure of sequences from Mus musculus with , and as ligands. Full crystallographic information is available from OCA.

Reference

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor., Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L, Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091

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