1z7s
From Proteopedia
(New page: 200px<br /><applet load="1z7s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z7s, resolution 3.20Å" /> '''The crystal structur...) |
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| - | [[Image:1z7s.gif|left|200px]]<br /><applet load="1z7s" size=" | + | [[Image:1z7s.gif|left|200px]]<br /><applet load="1z7s" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1z7s, resolution 3.20Å" /> | caption="1z7s, resolution 3.20Å" /> | ||
'''The crystal structure of coxsackievirus A21'''<br /> | '''The crystal structure of coxsackievirus A21'''<br /> | ||
==Overview== | ==Overview== | ||
| - | CVA21 and polioviruses both belong to the Enterovirus genus in the family | + | CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1. |
==About this Structure== | ==About this Structure== | ||
| - | 1Z7S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21] with CA, MYR and G as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1Z7S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MYR:'>MYR</scene> and <scene name='pdbligand=G:'>G</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7S OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human coxsackievirus a21]] | [[Category: Human coxsackievirus a21]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Bator-Kelly, C | + | [[Category: Bator-Kelly, C M.]] |
| - | [[Category: Chipman, P | + | [[Category: Chipman, P R.]] |
[[Category: Craig, A.]] | [[Category: Craig, A.]] | ||
| - | [[Category: Kuhn, R | + | [[Category: Kuhn, R J.]] |
[[Category: Rieder, E.]] | [[Category: Rieder, E.]] | ||
| - | [[Category: Rossmann, M | + | [[Category: Rossmann, M G.]] |
[[Category: Wimmer, E.]] | [[Category: Wimmer, E.]] | ||
[[Category: Xiao, C.]] | [[Category: Xiao, C.]] | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:56 2008'' |
Revision as of 14:12, 21 February 2008
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The crystal structure of coxsackievirus A21
Overview
CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.
About this Structure
1Z7S is a Protein complex structure of sequences from Human coxsackievirus a21 with , and as ligands. Full crystallographic information is available from OCA.
Reference
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874
Page seeded by OCA on Thu Feb 21 16:12:56 2008
Categories: Human coxsackievirus a21 | Protein complex | Bator-Kelly, C M. | Chipman, P R. | Craig, A. | Kuhn, R J. | Rieder, E. | Rossmann, M G. | Wimmer, E. | Xiao, C. | CA | G | MYR | A21 | Capsid protein | Coxsackievirus | Icosahedral virus | Picornavirus | Viral protein
