1zag
From Proteopedia
(New page: 200px<br /> <applet load="1zag" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zag, resolution 2.80Å" /> '''HUMAN ZINC-ALPHA-2-...) |
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| - | [[Image:1zag.gif|left|200px]]<br /> | + | [[Image:1zag.gif|left|200px]]<br /><applet load="1zag" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1zag" size=" | + | |
caption="1zag, resolution 2.80Å" /> | caption="1zag, resolution 2.80Å" /> | ||
'''HUMAN ZINC-ALPHA-2-GLYCOPROTEIN'''<br /> | '''HUMAN ZINC-ALPHA-2-GLYCOPROTEIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum | + | Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 angstrom crystal structure of ZAG resembles a class I major histocompatibility complex (MHC) heavy chain, but ZAG does not bind the class I light chain beta2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a nonpeptidic compound that may be implicated in lipid catabolism under normal or pathological conditions. |
==About this Structure== | ==About this Structure== | ||
| - | 1ZAG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and NDG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1ZAG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=NDG:'>NDG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bjorkman, P | + | [[Category: Bjorkman, P J.]] |
| - | [[Category: Chirino, A | + | [[Category: Chirino, A J.]] |
| - | [[Category: Sanchez, L | + | [[Category: Sanchez, L M.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: NDG]] | [[Category: NDG]] | ||
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[[Category: secreted mhc class i homolog]] | [[Category: secreted mhc class i homolog]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:13:44 2008'' |
Revision as of 14:13, 21 February 2008
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HUMAN ZINC-ALPHA-2-GLYCOPROTEIN
Overview
Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 angstrom crystal structure of ZAG resembles a class I major histocompatibility complex (MHC) heavy chain, but ZAG does not bind the class I light chain beta2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a nonpeptidic compound that may be implicated in lipid catabolism under normal or pathological conditions.
About this Structure
1ZAG is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules., Sanchez LM, Chirino AJ, Bjorkman P, Science. 1999 Mar 19;283(5409):1914-9. PMID:10206894
Page seeded by OCA on Thu Feb 21 16:13:44 2008
