2iu3

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[[Image:2iu3.png|left|200px]]
[[Image:2iu3.png|left|200px]]
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{{STRUCTURE_2iu3| PDB=2iu3 | SCENE= }}
{{STRUCTURE_2iu3| PDB=2iu3 | SCENE= }}
===CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE===
===CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE===
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{{ABSTRACT_PUBMED_17324932}}
{{ABSTRACT_PUBMED_17324932}}
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==Reference==
==Reference==
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<ref group="xtra">PMID:17324932</ref><ref group="xtra">PMID:15355974</ref><ref group="xtra">PMID:15615517</ref><ref group="xtra">PMID:11323713</ref><ref group="xtra">PMID:12501179</ref><ref group="xtra">PMID:12974624</ref><ref group="xtra">PMID:14756553</ref><ref group="xtra">PMID:14966129</ref><references group="xtra"/>
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<ref group="xtra">PMID:017324932</ref><ref group="xtra">PMID:015355974</ref><ref group="xtra">PMID:015615517</ref><ref group="xtra">PMID:011323713</ref><ref group="xtra">PMID:012501179</ref><ref group="xtra">PMID:012974624</ref><ref group="xtra">PMID:014756553</ref><ref group="xtra">PMID:014966129</ref><references group="xtra"/>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Amore, K.]]
[[Category: Amore, K.]]

Revision as of 13:17, 30 January 2013

Image:2iu3.png

Template:STRUCTURE 2iu3

CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE

Template:ABSTRACT PUBMED 17324932

About this Structure

2iu3 is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

  • Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282(17):13033-46. Epub 2007 Feb 26. PMID:17324932 doi:10.1074/jbc.M607293200
  • Xu L, Li C, Olson AJ, Wilson IA. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J Biol Chem. 2004 Nov 26;279(48):50555-65. Epub 2004 Sep 7. PMID:15355974 doi:10.1074/jbc.M406801200
  • Li C, Xu L, Wolan DW, Wilson IA, Olson AJ. Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors. J Med Chem. 2004 Dec 30;47(27):6681-90. PMID:15615517 doi:10.1021/jm049504o
  • Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nat Struct Biol. 2001 May;8(5):402-6. PMID:11323713 doi:http://dx.doi.org/10.1038/87555
  • Wolan DW, Greasley SE, Beardsley GP, Wilson IA. Structural insights into the avian AICAR transformylase mechanism. Biochemistry. 2002 Dec 31;41(52):15505-13. PMID:12501179
  • Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry. 2003 Sep 23;42(37):10904-14. PMID:12974624 doi:http://dx.doi.org/10.1021/bi030106h
  • Wolan DW, Cheong CG, Greasley SE, Wilson IA. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. Biochemistry. 2004 Feb 10;43(5):1171-83. PMID:14756553 doi:10.1021/bi030162i
  • Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:14966129 doi:10.1074/jbc.M313691200

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