1zhn
From Proteopedia
(New page: 200px<br /><applet load="1zhn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zhn, resolution 2.80Å" /> '''Crystal Structure of...) |
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| - | [[Image:1zhn.gif|left|200px]]<br /><applet load="1zhn" size=" | + | [[Image:1zhn.gif|left|200px]]<br /><applet load="1zhn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1zhn, resolution 2.80Å" /> | caption="1zhn, resolution 2.80Å" /> | ||
'''Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine'''<br /> | '''Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine'''<br /> | ||
==Overview== | ==Overview== | ||
| - | NKT cells are immunoregulatory lymphocytes whose activation is triggered | + | NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine. The interactions between the ligand acyl chains and the CD1d molecule define the structural and chemical requirements for the binding of lipid Ags to CD1d. The orientation of the polar headgroup toward the C terminus of the alpha1 helix provides a rationale for the structural basis for the observed Valpha chain bias in invariant NKT cells. The contribution of the ligand to the protein surface suggests a likely mode of recognition of lipid Ags by the NKT cell TCR. |
==About this Structure== | ==About this Structure== | ||
| - | 1ZHN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG, PC6 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1ZHN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=PC6:'>PC6</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bachi, A.]] | [[Category: Bachi, A.]] | ||
| - | [[Category: Crispin, M | + | [[Category: Crispin, M M.D.]] |
[[Category: Degano, M.]] | [[Category: Degano, M.]] | ||
[[Category: Giabbai, B.]] | [[Category: Giabbai, B.]] | ||
[[Category: Kronenberg, M.]] | [[Category: Kronenberg, M.]] | ||
| - | [[Category: Ruiz, Y | + | [[Category: Ruiz, Y Sanchez.]] |
[[Category: Sidobre, S.]] | [[Category: Sidobre, S.]] | ||
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: GOL]] | [[Category: GOL]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: mhc fold; antigen binding domain; ig fold]] | [[Category: mhc fold; antigen binding domain; ig fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:15:36 2008'' |
Revision as of 14:15, 21 February 2008
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Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine
Overview
NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine. The interactions between the ligand acyl chains and the CD1d molecule define the structural and chemical requirements for the binding of lipid Ags to CD1d. The orientation of the polar headgroup toward the C terminus of the alpha1 helix provides a rationale for the structural basis for the observed Valpha chain bias in invariant NKT cells. The contribution of the ligand to the protein surface suggests a likely mode of recognition of lipid Ags by the NKT cell TCR.
About this Structure
1ZHN is a Protein complex structure of sequences from Mus musculus with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation., Giabbai B, Sidobre S, Crispin MD, Sanchez-Ruiz Y, Bachi A, Kronenberg M, Wilson IA, Degano M, J Immunol. 2005 Jul 15;175(2):977-84. PMID:16002697
Page seeded by OCA on Thu Feb 21 16:15:36 2008
