1zhu
From Proteopedia
(New page: 200px<br /><applet load="1zhu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zhu" /> '''DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3')...) |
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| - | [[Image:1zhu.gif|left|200px]]<br /><applet load="1zhu" size=" | + | [[Image:1zhu.gif|left|200px]]<br /><applet load="1zhu" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1zhu" /> | caption="1zhu" /> | ||
'''DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES'''<br /> | '''DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | In certain contexts the DNA triplet GGA, when juxtaposed on opposite | + | In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases. |
==About this Structure== | ==About this Structure== | ||
| - | 1ZHU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1ZHU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHU OCA]. |
==Reference== | ==Reference== | ||
Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583654 7583654] | Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583654 7583654] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Chou, S | + | [[Category: Chou, S H.]] |
| - | [[Category: Reid, B | + | [[Category: Reid, B R.]] |
[[Category: Xu, J.]] | [[Category: Xu, J.]] | ||
[[Category: Zhu, L.]] | [[Category: Zhu, L.]] | ||
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[[Category: triplet diseases]] | [[Category: triplet diseases]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:15:44 2008'' |
Revision as of 14:15, 21 February 2008
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DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES
Overview
In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases.
About this Structure
1ZHU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:7583654
Page seeded by OCA on Thu Feb 21 16:15:44 2008
