1ziw
From Proteopedia
(New page: 200px<br /> <applet load="1ziw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ziw, resolution 2.10Å" /> '''Human Toll-like Rec...) |
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| - | [[Image:1ziw.gif|left|200px]]<br /> | + | [[Image:1ziw.gif|left|200px]]<br /><applet load="1ziw" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ziw" size=" | + | |
caption="1ziw, resolution 2.10Å" /> | caption="1ziw, resolution 2.10Å" /> | ||
'''Human Toll-like Receptor 3 extracellular domain structure'''<br /> | '''Human Toll-like Receptor 3 extracellular domain structure'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Toll-like receptors (TLRs) play key roles in activating immune responses | + | Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA. |
==About this Structure== | ==About this Structure== | ||
| - | 1ZIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NDG, NAG, SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1ZIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIW OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Choe, J.]] | [[Category: Choe, J.]] | ||
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: GOL]] | [[Category: GOL]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: innate immunity]] | [[Category: innate immunity]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:16:00 2008'' |
Revision as of 14:16, 21 February 2008
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Human Toll-like Receptor 3 extracellular domain structure
Overview
Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA.
About this Structure
1ZIW is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:15961631
Page seeded by OCA on Thu Feb 21 16:16:00 2008
Categories: Homo sapiens | Single protein | Choe, J. | Wilson, I A. | GOL | NAG | NDG | SO4 | Innate immunity
