This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Histone methyltransferase
From Proteopedia
| Line 7: | Line 7: | ||
== 3D Structures of histone methyltransferase == | == 3D Structures of histone methyltransferase == | ||
| - | ''Updated | + | ''Updated February 2013'' |
[[1nw3]] – hHMT DOT1L – human | [[1nw3]] – hHMT DOT1L – human | ||
| Line 22: | Line 22: | ||
[[3s8p]] - hKHMT Suv420H1<br /> | [[3s8p]] - hKHMT Suv420H1<br /> | ||
[[3mts]] - hKHMT Suv39H1 chromo domain<br /> | [[3mts]] - hKHMT Suv39H1 chromo domain<br /> | ||
| - | [[1h3i]] - hKHMT | + | [[1h3i]] - hKHMT Set7/9 residues 52-344<br /> |
| - | + | ||
| - | + | ||
[[2o8j]] - hKHMT H3K9 residues 913-1193<br /> | [[2o8j]] - hKHMT H3K9 residues 913-1193<br /> | ||
| - | [[ | + | [[2lv9]] - hKHMT Mll5 residues 109-188 - NMR<br /> |
[[3n71]] - hKHMT Smyd1<br /> | [[3n71]] - hKHMT Smyd1<br /> | ||
| - | [[ | + | [[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> |
| + | [[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | ||
| + | [[1u2z]] – yKHMT C terminal | ||
| + | ===Histone-lysine N-methyltransferase complexes=== | ||
| + | |||
| + | [[3rib]] – hKHMT Smyd2 + SAH<br /> | ||
| + | [[1o9s]] - hKHMT Set7/9 residues 52-344 + H3 peptide<br /> | ||
| + | [[2bqz]] - hKHMT Set7 residues 192-352 + H4 peptide<br /> | ||
| + | [[1mt6]] - hKHMT Set7/9 residues 58-337 + SAH<br /> | ||
| + | [[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + H3 peptide<br /> | ||
| + | [[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br /> | ||
| + | [[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | ||
[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor | [[3s7b]] - hKHMT Smyd2 + SAM + inhibitor | ||
| Line 35: | Line 44: | ||
[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | [[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | ||
| - | [[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | ||
[[1peg]] - NcKHMT Dim-5 + H3 peptide<br /> | [[1peg]] - NcKHMT Dim-5 + H3 peptide<br /> | ||
| - | [[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | ||
[[2g46]] – PvKHMT + SAH + H3 peptide<br /> | [[2g46]] – PvKHMT + SAH + H3 peptide<br /> | ||
| - | + | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:09, 6 February 2013
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.
Contents |
3D Structures of histone methyltransferase
Updated February 2013
1nw3 – hHMT DOT1L – human
2igq – hHMT-1 C terminal
Histone-lysine N-methyltransferase
2j8a – KHMT SET1 RRM domain – yeast
3s8s – hKHMT SETD1A RRM domain
2r3a – hKHMT Suv39H2
3rq4 - hKHMT Suv420H2
3s8p - hKHMT Suv420H1
3mts - hKHMT Suv39H1 chromo domain
1h3i - hKHMT Set7/9 residues 52-344
2o8j - hKHMT H3K9 residues 913-1193
2lv9 - hKHMT Mll5 residues 109-188 - NMR
3n71 - hKHMT Smyd1
1ml9 – NcKHMT Dim-5 – Neurospora crassa
1n3j – PvKHMT – Paramecium bursaria chlorella virus
1u2z – yKHMT C terminal
Histone-lysine N-methyltransferase complexes
3rib – hKHMT Smyd2 + SAH
1o9s - hKHMT Set7/9 residues 52-344 + H3 peptide
2bqz - hKHMT Set7 residues 192-352 + H4 peptide
1mt6 - hKHMT Set7/9 residues 58-337 + SAH
2rfi, 3hna - hKHMT H3K9 catalytic domain + H3 peptide
3b95 - hKHMT ankyrin repeat domain + H3 peptide
3lqi, 3lqj - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide
3s7b - hKHMT Smyd2 + SAM + inhibitor
3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide
3s7j, 3tg4 - hKHMT Smyd2 + SAM
1peg - NcKHMT Dim-5 + H3 peptide
2g46 – PvKHMT + SAH + H3 peptide
