1zoq
From Proteopedia
(New page: 200px<br /> <applet load="1zoq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zoq, resolution 2.37Å" /> '''IRF3-CBP complex'''...) |
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| - | [[Image:1zoq.gif|left|200px]]<br /> | + | [[Image:1zoq.gif|left|200px]]<br /><applet load="1zoq" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1zoq" size=" | + | |
caption="1zoq, resolution 2.37Å" /> | caption="1zoq, resolution 2.37Å" /> | ||
'''IRF3-CBP complex'''<br /> | '''IRF3-CBP complex'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Interferon regulatory factor (IRF) 3 plays a critical role in triggering | + | Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZOQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http:// | + | 1ZOQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:38 2008'' |
Revision as of 14:17, 21 February 2008
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IRF3-CBP complex
Contents |
Overview
Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.
Disease
Known diseases associated with this structure: Blue-cone monochromacy OMIM:[303900], Colorblindness, protan OMIM:[303900], Rubenstein-Taybi syndrome OMIM:[600140]
About this Structure
1ZOQ is a Protein complex structure of sequences from Homo sapiens. Active as Histone acetyltransferase, with EC number 2.3.1.48 Full crystallographic information is available from OCA.
Reference
IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:16154077
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