1zye
From Proteopedia
(New page: 200px<br /><applet load="1zye" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zye, resolution 3.30Å" /> '''Crystal strucutre an...) |
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| - | [[Image:1zye.gif|left|200px]]<br /><applet load="1zye" size=" | + | [[Image:1zye.gif|left|200px]]<br /><applet load="1zye" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1zye, resolution 3.30Å" /> | caption="1zye, resolution 3.30Å" /> | ||
'''Crystal strucutre analysis of Bovine Mitochondrial Peroxiredoxin III'''<br /> | '''Crystal strucutre analysis of Bovine Mitochondrial Peroxiredoxin III'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A crystal structure is reported for the C168S mutant of a typical 2-Cys | + | A crystal structure is reported for the C168S mutant of a typical 2-Cys peroxiredoxin III (Prx III) from bovine mitochondria at a resolution of 3.3 A. Prx III is present as a two-ring catenane comprising two interlocking dodecameric toroids that are assembled from basic dimeric units. Each ring has an external diameter of 150 A and encompasses a central cavity that is 70 A in width. The concatenated dodecamers are inclined at an angle of 55 degrees, which provides a large contact surface between the rings. Dimer-dimer contacts involved in toroid formation are hydrophobic in nature, whereas the 12 areas of contact between interlocked rings arise from polar interactions. These two major modes of subunit interaction provide important insights into possible mechanisms of catenane formation. |
==About this Structure== | ==About this Structure== | ||
| - | 1ZYE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Active as [http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] Full crystallographic information is available from [http:// | + | 1ZYE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Active as [http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cao, Z.]] | [[Category: Cao, Z.]] | ||
| - | [[Category: Gourlay, L | + | [[Category: Gourlay, L J.]] |
| - | [[Category: Isaacs, N | + | [[Category: Isaacs, N W.]] |
| - | [[Category: Lindsay, J | + | [[Category: Lindsay, J G.]] |
| - | [[Category: Roszak, A | + | [[Category: Roszak, A W.]] |
[[Category: catenane]] | [[Category: catenane]] | ||
[[Category: dodecamer]] | [[Category: dodecamer]] | ||
[[Category: peroxiredoxin]] | [[Category: peroxiredoxin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:20:15 2008'' |
Revision as of 14:20, 21 February 2008
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Crystal strucutre analysis of Bovine Mitochondrial Peroxiredoxin III
Overview
A crystal structure is reported for the C168S mutant of a typical 2-Cys peroxiredoxin III (Prx III) from bovine mitochondria at a resolution of 3.3 A. Prx III is present as a two-ring catenane comprising two interlocking dodecameric toroids that are assembled from basic dimeric units. Each ring has an external diameter of 150 A and encompasses a central cavity that is 70 A in width. The concatenated dodecamers are inclined at an angle of 55 degrees, which provides a large contact surface between the rings. Dimer-dimer contacts involved in toroid formation are hydrophobic in nature, whereas the 12 areas of contact between interlocked rings arise from polar interactions. These two major modes of subunit interaction provide important insights into possible mechanisms of catenane formation.
About this Structure
1ZYE is a Single protein structure of sequence from Bos taurus. Active as Peroxiredoxin, with EC number 1.11.1.15 Full crystallographic information is available from OCA.
Reference
Bovine mitochondrial peroxiredoxin III forms a two-ring catenane., Cao Z, Roszak AW, Gourlay LJ, Lindsay JG, Isaacs NW, Structure. 2005 Nov;13(11):1661-4. PMID:16271889
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