3f7g
From Proteopedia
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[[Image:3f7g.png|left|200px]] | [[Image:3f7g.png|left|200px]] | ||
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{{STRUCTURE_3f7g| PDB=3f7g | SCENE= }} | {{STRUCTURE_3f7g| PDB=3f7g | SCENE= }} | ||
===Structure of the BIR domain from ML-IAP bound to a peptidomimetic=== | ===Structure of the BIR domain from ML-IAP bound to a peptidomimetic=== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019228017</ref><ref group="xtra">PMID:017168540</ref><ref group="xtra">PMID:015485396</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cohen, F.]] | [[Category: Cohen, F.]] | ||
[[Category: Fairbrother, W J.]] | [[Category: Fairbrother, W J.]] | ||
[[Category: Franklin, M C.]] | [[Category: Franklin, M C.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Apoptosis inhibition]] | [[Category: Apoptosis inhibition]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
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[[Category: Peptide complex]] | [[Category: Peptide complex]] | ||
[[Category: Peptidomimetic]] | [[Category: Peptidomimetic]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Small molecule]] | [[Category: Small molecule]] | ||
| - | [[Category: Zinc]] | ||
[[Category: Zinc binding]] | [[Category: Zinc binding]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 10:54, 13 February 2013
Structure of the BIR domain from ML-IAP bound to a peptidomimetic
Template:ABSTRACT PUBMED 19228017
About this Structure
3f7g is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem. 2009 Mar 26;52(6):1723-30. PMID:19228017 doi:10.1021/jm801450c
- Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol. 2006 Sep 19;1(8):525-33. PMID:17168540 doi:10.1021/cb600276q
- Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 1;385(Pt 1):11-20. PMID:15485396 doi:10.1042/BJ20041108
