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244d
From Proteopedia
(New page: 200px<br /><applet load="244d" size="350" color="white" frame="true" align="right" spinBox="true" caption="244d, resolution 1.200Å" /> '''THE HIGH-RESOLUTION...) |
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==Overview== | ==Overview== | ||
| - | Repeat tracts of guanine bases found in DNA and RNA can form tetraplex | + | Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Laughlan, G.]] | [[Category: Laughlan, G.]] | ||
| - | [[Category: Lilley, D | + | [[Category: Lilley, D M.J.]] |
[[Category: Luisi, B.]] | [[Category: Luisi, B.]] | ||
| - | [[Category: Moody, P | + | [[Category: Moody, P C.E.]] |
| - | [[Category: Moore, M | + | [[Category: Moore, M H.]] |
| - | [[Category: Murchie, A | + | [[Category: Murchie, A I.H.]] |
| - | [[Category: Norman, D | + | [[Category: Norman, D G.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: NA]] | [[Category: NA]] | ||
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[[Category: unusual dna]] | [[Category: unusual dna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:21:38 2008'' |
Revision as of 14:21, 21 February 2008
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THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX
Overview
Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
About this Structure
244D is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:8036494
Page seeded by OCA on Thu Feb 21 16:21:38 2008
