3fli
From Proteopedia
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Revision as of 11:11, 13 February 2013
Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)
Template:ABSTRACT PUBMED 19159286
About this Structure
3fli is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Flatt B, Martin R, Wang TL, Mahaney P, Murphy B, Gu XH, Foster P, Li J, Pircher P, Petrowski M, Schulman I, Westin S, Wrobel J, Yan G, Bischoff E, Daige C, Mohan R. Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). J Med Chem. 2009 Feb 26;52(4):904-7. PMID:19159286 doi:10.1021/jm8014124
Categories: Homo sapiens | Foster, P G. | Stout, T J. | Activator | Alpha-helical sandwich | Bar | Bile acid receptor | Dna-binding | Fxr | Ligand-binding domain | Metal-binding | Nr1h4 | Nuclear receptor | Nucleus | Receptor | Repressor | Transcription | Transcription regulation | Transcriptional regulator | Zinc-finger
